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The reigning Super Bowl champs reside in the NFC West, and the division looks to be a formidable one, at least outside of a rebuilding Seattle squad.
We continue to roll out weekly spreads for each team of every division. In the sixth week, we take a look at the 49ers, Cardinals, Rams and Seahawks.
Beyond the week-by-week spreads, below you can see each team’s Super Bowl, conference and division odds. There are also the latest victory totals and playoff chances.
Please note that Week 17 and Week 18 spreads are not available below due to uncertainty in playoff standings, playing statuses, schedules, etc.
Week 1
49ers at Bears (+6)
Broncos at Seahawks (+5)
Chiefs at Cardinals (+3)
Bills at Rams (+1.5) original line was Rams -1
Week 2
Seahawks at 49ers (-9)
Falcons at Rams (-13)
Cardinals at Raiders (-2.5)
Week 3
Falcons at Seahawks (-5)
49ers at Broncos (-1.5)
Rams at Cardinals (+1)
Week 4
Cardinals at Panthers (+2.5)
Seahawks at Lions (-2.5) original line was Lions +1.5
Rams at 49ers (-1)
Week 5
Seahawks at Saints (-4.5) original line was -5.5
Cowboys at Rams (-4)
Eagles at Cardinals (-1) original line was -3
49ers at Panthers (+2.5) original line was +4
Week 6
49ers at Falcons (+7)
Panthers at Rams (-9)
Cardinals at Seahawks (+2.5)
Week 7
Saints at Cardinals (-3.5)
Seahawks at Chargers (-9.5)
Chiefs at 49ers (+1)
Week 8
Giants at Seahawks (-3.5) original line was -3.5
Cardinals at Vikings (-1.5) original line was -3
49ers at Rams (-2.5)
Week 9
Seahawks at Cardinals (-6.5)
Rams at Bucs (-1.5) original line was -3.5
Week 10
Seahawks at Bucs (-11)
Chargers at 49ers (-2.5)
Cardinals at Rams (-4.5)
Week 11
Rams at Saints (+2)
49ers at Cardinals (+1)
Week 12
Chargers at Cardinals (PK)
Raiders at Seahawks (+1)
Saints at 49ers (-5)
Rams at Chiefs (-2.5)
Week 13
Seahawks at Rams (-10)
Dolphins at 49ers (-5) original line was -6
Week 14
Patriots at Cardinals (-2.5)
Panthers at Seahawks (-1.5) original line was -3
Raiders at Rams (-7)
Bucs at 49ers (+2)
Week 15
Cardinals at Broncos (-3.5)
Rams at Packers (-1.5) original line was -3
49ers at Seahawks (+4.5)
Week 16
Commanders at 49ers (-5.5) original line was -9.5
Seahawks at Chiefs (-11)
Broncos at Rams (-4)
Bucs at Cardinals (+3)
AFC South futures: https://www.betonline.ag/sportsbook/futures-and-props/nfl-futures
49ers Odds
Super Bowl: +2000
NFC: +800
Division: +210
Victories: Over/Under 9.5
Playoffs: Yes -200, No +160
Cardinals Odds
Super Bowl: +4000
NFC: +1600
Division: +285
Victories: Over/Under 8.5
Playoffs: Yes +120, No -150
Rams Odds
Super Bowl: +3300
NFC: +450
Division: +130
Victories: Over/Under 10.5
Playoffs: Yes -250, No +195
Seahawks Odds
Super Bowl: +12500
NFC: +5000
Division: +1000
Victories: Over/Under 5.5
Playoffs: Yes +400, No -600
