Kansas City Chiefs – Indianapolis Colts Betting Preview

Submitted by Carrie Stroup on

Written by :

Carrie Stroup

Published on :

Carrie Stroup here for Gambling911.com with your Kansas City Chiefs – Indianapolis Colts betting preview. 

Talk about no respect. The Kansas City Chiefs are the last remaining unbeaten team yet they are the biggest underdogs of the week as they travel to play the 2-2 Indianapolis Colts Sunday. Sportsbook.com currently has the point spread for this game at Chiefs +7 points while the ‘total’ is a lofty 45.5 points.

Kansas City crushed San Francisco 31-10 in Week 3 before resting with a bye. Indianapolis lost a 31-28 heart-breaker at Jacksonville when Josh Scobee won the game at the buzzer with a 59-yard field goal.

Kansas City’s defense has been excellent, holding each of its first three opponents to 14 points or fewer.  The Chiefs limited their last two opponents to just 275 YPG including a measly 58 rushing YPG. The offense has played pretty well too, ranking third in the NFL with 161 rushing YPG. Jamal Charles (79 rush YPG) and Thomas Jones (72 rush YPG) have done a great job splitting carries this year. QB Matt Cassel was very efficient against the 49ers last game with 250 passing yards, three touchdowns and just one interception.

Despite the two losses, Peyton Manning has been amazing. He has completed 70 percent of his passes for 1,365 yards, 11 TD and just 1 INT. It’s the running game that has had problems, gaining a total of just 102 yards in its two losses and ranking 29th in the NFL with 76 rush YPG. Indy also ranks 29th in rushing defense, surrendering 150 rush YPG.

The Colts are 7-2 ATS in the series since 1992. This football betting trend found at Sportsbook.com supports another Indy cover.

Play Against - Road teams (KANSAS CITY) - off 2 or more consecutive upset wins as an underdog, with a winning record on the season. (49-22 since 1983.) (69%, +24.8 units. Rating = 2*).

After checking out Sportsbook.com’s NFL betting trends it appears as if 94 percent of the early bettors are backing the ‘Over’. Here is a trend to support those one-sided numbers:

Play Over - Road teams where the total is between 42.5 and 49 points (KANSAS CITY) - off a home blowout win by 21 points or more, undefeated on the season. (22-4 since 1983.) (84.6%, +17.6 units. Rating = 3*).

Head over to Sportsbook.com now to check out all of the football betting odds for this weekend. After placing your bets be sure to make your picks for the $100,000 Perfect Parlay promo.

Related Content

2026 NFL Draft

2026 NFL Draft Betting Action, Biggest Liabilities

The guys at BetOnline.ag have graciously shared some interesting betting data ahead of the draft, which is now just about 24 hours away.
Denzel Boston

What Are Denzel Boston NFL Draft Position Odds Over, Under?

Denzel Boston had an over/under of 26.5 Draft position coming into Thursday
Chris Johnson

What Are Chris Johnson NFL Draft Position Odds Over, Under?

Chris Johnson was coming in with an over/under pick position of 31.5 for Thursday's NFL Draft.
Akheem Mesidor

What Are Akheem Mesidor NFL Draft Position Odds Over, Under?

Akheem Mesidor's pick position for the 2026 NFL Draft was coming in at over/under 25.5